Hi!
While using a vShield Manager (5.5.4-2673026) we encountered an issue when CPU usage is almost 100% from time to time and the only solution than helps to solve the problem is to reboot the virtual machine.
Aside from vShield Manager we have four ESXi hosts with vShield App installed on each of them. Number of VMs - around 800.
We also tried to increase a number of CPU and Memory on VM - 6vCPU and 24576MB Memory