VMware ESXi scale up vs. scale out

Hi there........

Were reviewing our VMware practice and would like to know the general practice out there in VMware Cluster implementation - is it more common to Scale-Out or Scale-Up the servers eg. use 4-Way Servers vs. 2-Way Servers?

Obviously 4-Way will provide greater level of consolidation and VM density due to vCPU count while 2-Way will be lower but are there any other arguments eg. placing less of your eggs in one basket. From a cost perspective it would seem 4-Way will be more cost effective.

Any comments..

Cheers........